Out on Court 2, third-seeded Stefanos Tsitsipas of Greece was far from his best in a 2-6, 7-6 (4), 6-2 loss to 14th-seeded Ugo Humbert of France. Also, 12th-seeded Karen Khachanov of ROC eliminated eighth-seeded Diego Schwartzman of Argentina 6-1, 2-6, 6-1.